Proteases and proteomics: Cutting to the core of human skin pathologies
Identifieur interne : 000064 ( Istex/Checkpoint ); précédent : 000063; suivant : 000065Proteases and proteomics: Cutting to the core of human skin pathologies
Auteurs : Simon J. De Veer [France, Australie] ; Laetitia Furio [France] ; Jonathan M. Harris [Australie] ; Alain Hovnanian [France]Source :
- PROTEOMICS – Clinical Applications [ 1862-8346 ] ; 2014-06.
Abstract
Preserving the integrity of the skin's outermost layer (the epidermis) is vital for humans to thrive in hostile surroundings. Covering the entire body, the epidermis forms a thin but impenetrable cellular cordon that repels external assaults and blocks escape of water and electrolytes from within. This structure exists in a perpetual state of regeneration where the production of new cellular subunits at the base of the epidermis is offset by the release of terminally differentiated corneocytes from the surface. It is becoming increasingly clear that proteases hold vital roles in assembling and maintaining the epidermal barrier. More than 30 proteases are expressed by keratinocytes or infiltrating immune cells and the activity of each must be maintained within narrow limits and confined to the correct time and place. Accordingly, over‐ or under‐exertion of proteolytic activity is a common factor in a multitude of skin disorders that range in severity from relatively mild to life‐threatening. This review explores the current state of knowledge on the involvement of proteases in skin diseases and the latest findings from proteomic and transcriptomic studies focused on uncovering novel (patho)physiological roles for these enzymes.
Url:
DOI: 10.1002/prca.201300081
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
ISTEX:8F58DCC8457926A416193B4F5E5198A3D1D65D54Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Proteases and proteomics: Cutting to the core of human skin pathologies</title><author><name sortKey="De Veer, Simon J" sort="De Veer, Simon J" uniqKey="De Veer S" first="Simon J." last="De Veer">Simon J. De Veer</name></author><author><name sortKey="Furio, Laetitia" sort="Furio, Laetitia" uniqKey="Furio L" first="Laetitia" last="Furio">Laetitia Furio</name></author><author><name sortKey="Harris, Jonathan M" sort="Harris, Jonathan M" uniqKey="Harris J" first="Jonathan M." last="Harris">Jonathan M. Harris</name></author><author><name sortKey="Hovnanian, Alain" sort="Hovnanian, Alain" uniqKey="Hovnanian A" first="Alain" last="Hovnanian">Alain Hovnanian</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:8F58DCC8457926A416193B4F5E5198A3D1D65D54</idno><date when="2014" year="2014">2014</date><idno type="doi">10.1002/prca.201300081</idno><idno type="url">https://api.istex.fr/document/8F58DCC8457926A416193B4F5E5198A3D1D65D54/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001B04</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001B04</idno><idno type="wicri:Area/Istex/Curation">001B04</idno><idno type="wicri:Area/Istex/Checkpoint">000064</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000064</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Proteases and proteomics: Cutting to the core of human skin pathologies</title><author><name sortKey="De Veer, Simon J" sort="De Veer, Simon J" uniqKey="De Veer S" first="Simon J." last="De Veer">Simon J. De Veer</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Descartes – Sorbonne Paris Cité, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR 1163, Laboratory of Genetic Skin Diseases, Imagine Institute, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Furio, Laetitia" sort="Furio, Laetitia" uniqKey="Furio L" first="Laetitia" last="Furio">Laetitia Furio</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Descartes – Sorbonne Paris Cité, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR 1163, Laboratory of Genetic Skin Diseases, Imagine Institute, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Harris, Jonathan M" sort="Harris, Jonathan M" uniqKey="Harris J" first="Jonathan M." last="Harris">Jonathan M. Harris</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Hovnanian, Alain" sort="Hovnanian, Alain" uniqKey="Hovnanian A" first="Alain" last="Hovnanian">Alain Hovnanian</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Descartes – Sorbonne Paris Cité, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR 1163, Laboratory of Genetic Skin Diseases, Imagine Institute, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Department of Genetics, Necker Hospital for Sick Children, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>: Professor Alain Hovnanian, CHU Necker‐Enfants malades, Department of Genetics, Tour Lavoisier, 3 étage, 149 rue de Sèvres, 75743 Paris cedex 15</wicri:regionArea><wicri:noRegion>75743 Paris cedex 15</wicri:noRegion><wicri:noRegion>75743 Paris cedex 15</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">France</country></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">PROTEOMICS – Clinical Applications</title><title level="j" type="sub">Proteases and Disease</title><title level="j" type="alt">PROTEOMICS CLINICAL APPLICATIONS</title><idno type="ISSN">1862-8346</idno><idno type="eISSN">1862-8354</idno><imprint><biblScope unit="vol">8</biblScope><biblScope unit="issue">5-6</biblScope><biblScope unit="page" from="389">389</biblScope><biblScope unit="page" to="402">402</biblScope><biblScope unit="page-count">14</biblScope><date type="published" when="2014-06">2014-06</date></imprint><idno type="ISSN">1862-8346</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1862-8346</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Preserving the integrity of the skin's outermost layer (the epidermis) is vital for humans to thrive in hostile surroundings. Covering the entire body, the epidermis forms a thin but impenetrable cellular cordon that repels external assaults and blocks escape of water and electrolytes from within. This structure exists in a perpetual state of regeneration where the production of new cellular subunits at the base of the epidermis is offset by the release of terminally differentiated corneocytes from the surface. It is becoming increasingly clear that proteases hold vital roles in assembling and maintaining the epidermal barrier. More than 30 proteases are expressed by keratinocytes or infiltrating immune cells and the activity of each must be maintained within narrow limits and confined to the correct time and place. Accordingly, over‐ or under‐exertion of proteolytic activity is a common factor in a multitude of skin disorders that range in severity from relatively mild to life‐threatening. This review explores the current state of knowledge on the involvement of proteases in skin diseases and the latest findings from proteomic and transcriptomic studies focused on uncovering novel (patho)physiological roles for these enzymes.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="De Veer, Simon J" sort="De Veer, Simon J" uniqKey="De Veer S" first="Simon J." last="De Veer">Simon J. De Veer</name></region><name sortKey="De Veer, Simon J" sort="De Veer, Simon J" uniqKey="De Veer S" first="Simon J." last="De Veer">Simon J. De Veer</name><name sortKey="Furio, Laetitia" sort="Furio, Laetitia" uniqKey="Furio L" first="Laetitia" last="Furio">Laetitia Furio</name><name sortKey="Furio, Laetitia" sort="Furio, Laetitia" uniqKey="Furio L" first="Laetitia" last="Furio">Laetitia Furio</name><name sortKey="Hovnanian, Alain" sort="Hovnanian, Alain" uniqKey="Hovnanian A" first="Alain" last="Hovnanian">Alain Hovnanian</name><name sortKey="Hovnanian, Alain" sort="Hovnanian, Alain" uniqKey="Hovnanian A" first="Alain" last="Hovnanian">Alain Hovnanian</name><name sortKey="Hovnanian, Alain" sort="Hovnanian, Alain" uniqKey="Hovnanian A" first="Alain" last="Hovnanian">Alain Hovnanian</name><name sortKey="Hovnanian, Alain" sort="Hovnanian, Alain" uniqKey="Hovnanian A" first="Alain" last="Hovnanian">Alain Hovnanian</name><name sortKey="Hovnanian, Alain" sort="Hovnanian, Alain" uniqKey="Hovnanian A" first="Alain" last="Hovnanian">Alain Hovnanian</name></country><country name="Australie"><noRegion><name sortKey="De Veer, Simon J" sort="De Veer, Simon J" uniqKey="De Veer S" first="Simon J." last="De Veer">Simon J. De Veer</name></noRegion><name sortKey="Harris, Jonathan M" sort="Harris, Jonathan M" uniqKey="Harris J" first="Jonathan M." last="Harris">Jonathan M. Harris</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Istex/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000064 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Checkpoint/biblio.hfd -nk 000064 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Istex
|étape= Checkpoint
|type= RBID
|clé= ISTEX:8F58DCC8457926A416193B4F5E5198A3D1D65D54
|texte= Proteases and proteomics: Cutting to the core of human skin pathologies
}}
| This area was generated with Dilib version V0.6.33. |  |